Saint Macedonia was martyred during the persecution in the reign of Decius (249-251), along with Saints Pionius and Limnus, Sabina, and Asclepiades. They suffered at Smyrna, a mercantile city on the eastern shores of the Aegean Sea.
Saint Macedonia was from the village of Karine. She and her husband Limnus, a priest of the Church of Smyrna, had been cast into prison for confessing Christ. That is where Saint Pionius and his companions met them.
The Life of Saint Pionius does not record the details of the martyrdom of Saints Limnus or Macedonia.